[Severe acute respiratory syndrome (SARS)].
Identifieur interne : 001079 ( Main/Exploration ); précédent : 001078; suivant : 001080[Severe acute respiratory syndrome (SARS)].
Auteurs : G. Hoheisel [Allemagne] ; A. Wu ; N. Lee ; C H Chan ; K T Wong ; A. Ahuja ; G M Joynt ; S C Chung ; J J Y. Sung ; D S HuiSource :
- Pneumologie (Stuttgart, Germany) [ 0934-8387 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte, Diagnostic différentiel, Femelle, Humains, Mâle, Pneumopathie infectieuse (diagnostic), Radiographie, Sujet âgé, Syndrome de détresse respiratoire de l'adulte (physiopathologie), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (imagerie diagnostique), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité), Évolution de la maladie.
- MESH :
- diagnostic : Pneumopathie infectieuse, Syndrome respiratoire aigu sévère.
- imagerie diagnostique : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome de détresse respiratoire de l'adulte.
- virologie : Syndrome respiratoire aigu sévère.
- transmission : Adulte, Diagnostic différentiel, Femelle, Humains, Mâle, Radiographie, Sujet âgé, Syndrome respiratoire aigu sévère, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Diagnosis, Differential, Disease Progression, Female, Humans, Male, Pneumonia (diagnosis), Radiography, Respiratory Distress Syndrome, Adult (physiopathology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (diagnostic imaging), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology).
- MESH :
- diagnosis : Pneumonia, Severe Acute Respiratory Syndrome.
- diagnostic imaging : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- physiopathology : Respiratory Distress Syndrome, Adult.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Adult, Aged, Diagnosis, Differential, Disease Progression, Female, Humans, Male, Radiography.
Abstract
The severe acute respiratory syndrome (SARS) is a highly infectious respiratory disease, to the best of our knowledge caused by a hitherto unknown corona virus. The virus has spread from South East Asia to many countries of the world. Three case reports of patients from the Prince of Wales Hospital of The Chinese University of Hong Kong demonstrate typical clinical courses. Fever, cough, in most cases non-productive, myalgia, chills, and rigor are the leading symptoms. Leucopenia and thrombocytopenia are the most prominent laboratory parameters, increased values for lactatedehydrogenase (LDH) reflect a more severe clinical course. Advanced age and coexisting conditions seem to influence the prognosis unfavourably. The chest roentgenogram may be normal initially but at a later stage progressive consolidations in the majority of peripheral parts of the lung are observed, which cannot be differentiated from pneumonias of other origin. Even young patients can enter a stage of respiratory compromise rather fast. A therapy against the cause of the disease is not known. Empirical therapy with ribavirin in combination with high dose corticosteroids have proved successful. The disease may progress into respiratory failure comparable with an acute respiratory distress syndrome (ARDS). Mortality is around five to ten per cent. Stringent hygiene and quarantine measures are mandatory to prevent the further spread of this threatening disease.
DOI: 10.1055/s-2003-40049
PubMed: 12813666
Affiliations:
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Le document en format XML
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Ahuja</name></author><author><name sortKey="Joynt, G M" sort="Joynt, G M" uniqKey="Joynt G" first="G M" last="Joynt">G M Joynt</name></author><author><name sortKey="Chung, S C" sort="Chung, S C" uniqKey="Chung S" first="S C" last="Chung">S C Chung</name></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J Y" last="Sung">J J Y. Sung</name></author><author><name sortKey="Hui, D S" sort="Hui, D S" uniqKey="Hui D" first="D S" last="Hui">D S Hui</name></author></analytic><series><title level="j">Pneumologie (Stuttgart, Germany)</title><idno type="ISSN">0934-8387</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Pneumonia (diagnosis)</term><term>Radiography</term><term>Respiratory Distress Syndrome, Adult (physiopathology)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (diagnostic imaging)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pneumopathie infectieuse (diagnostic)</term><term>Radiographie</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (imagerie diagnostique)</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (pathogénicité)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pneumonia</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Pneumopathie infectieuse</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Radiography</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Adulte</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Radiographie</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome (SARS) is a highly infectious respiratory disease, to the best of our knowledge caused by a hitherto unknown corona virus. The virus has spread from South East Asia to many countries of the world. Three case reports of patients from the Prince of Wales Hospital of The Chinese University of Hong Kong demonstrate typical clinical courses. Fever, cough, in most cases non-productive, myalgia, chills, and rigor are the leading symptoms. Leucopenia and thrombocytopenia are the most prominent laboratory parameters, increased values for lactatedehydrogenase (LDH) reflect a more severe clinical course. Advanced age and coexisting conditions seem to influence the prognosis unfavourably. The chest roentgenogram may be normal initially but at a later stage progressive consolidations in the majority of peripheral parts of the lung are observed, which cannot be differentiated from pneumonias of other origin. Even young patients can enter a stage of respiratory compromise rather fast. A therapy against the cause of the disease is not known. Empirical therapy with ribavirin in combination with high dose corticosteroids have proved successful. The disease may progress into respiratory failure comparable with an acute respiratory distress syndrome (ARDS). Mortality is around five to ten per cent. Stringent hygiene and quarantine measures are mandatory to prevent the further spread of this threatening disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Ahuja, A" sort="Ahuja, A" uniqKey="Ahuja A" first="A" last="Ahuja">A. Ahuja</name><name sortKey="Chan, C H" sort="Chan, C H" uniqKey="Chan C" first="C H" last="Chan">C H Chan</name><name sortKey="Chung, S C" sort="Chung, S C" uniqKey="Chung S" first="S C" last="Chung">S C Chung</name><name sortKey="Hui, D S" sort="Hui, D S" uniqKey="Hui D" first="D S" last="Hui">D S Hui</name><name sortKey="Joynt, G M" sort="Joynt, G M" uniqKey="Joynt G" first="G M" last="Joynt">G M Joynt</name><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N" last="Lee">N. Lee</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J Y" last="Sung">J J Y. Sung</name><name sortKey="Wong, K T" sort="Wong, K T" uniqKey="Wong K" first="K T" last="Wong">K T Wong</name><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Hoheisel, G" sort="Hoheisel, G" uniqKey="Hoheisel G" first="G" last="Hoheisel">G. 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